Blar i NILU Brage på forfatter "Kohl, Yvonne"
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Genotoxicity of Nanomaterials: Advanced In Vitro Models and High Throughput Methods for Human Hazard Assessment - A Review
Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria (Peer reviewed; Journal article, 2020)Changes in the genetic material can lead to serious human health defects, as mutations in somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic events can appear at both the DNA, chromosomal ... -
Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise (Peer reviewed; Journal article, 2020)(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures ... -
Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening
Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar Hernando; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Rundén-Pran, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; Knoll, Thorsten (Peer reviewed; Journal article, 2021)Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal‐free risk assessment of new chemicals and drugs. Microfluidic cell‐based devices ... -
Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival
Urbanova, Maria; Cihova, Marina; Buocikova, Verona; Slopovsky, Jan; Dubovan, Peter; Pindak, Daniel; Tomas, Miroslav; García-Bermejo, Laura; Rodríguez-Garrote, Mercedes; Earl, Julie; Kohl, Yvonne; Kataki, Agapi; Dusinska, Maria; Sainz Jr., Bruno; Smolkova, Bozena; Gabelova, Alena (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate tumor progression and ... -
Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation
Dubaj, Tibor; Kozics, Katarina; Srámková, Monika; Manova, Alena; Bastus, Neus G.; Moriones, Oscar H.; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise; Puntes, Victor; Nelson, Andrew; Gábelová, Alena; Simon, Peter (Peer reviewed; Journal article, 2022)Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies ... -
Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform
Kohl, Yvonne; William, Nicola; Elje, Elisabeth; Backes, Nadine; Rothbauer, Mario; Srancikova, Annamaria; Rundén-Pran, Elise; El Yamani, Naouale; Korenstein, Rafi; Madi, Lea; Barbul, Alexander; Kozics, Katarina; Sramkova, Monika; Steenson, Karen; Gabelova, Alena; Ertl, Peter; Dusinska, Maria; Nelson, Andrew (Peer reviewed; Journal article, 2023)This study compares the performance and output of an electrochemical phospholipid membrane platform against respective in vitro cell-based toxicity testing methods using three toxicants of different biological action ... -
Safety-by-design and engineered nanomaterials: the need to move from theory to practice
Trump, Benjamin D.; Antunes, Dalila; Palma-Oliveira, José; Nelson, Andrew; Hudecova, Alexandra Misci; Rundén-Pran, Elise; Dusinska, Maria; Gispert, Ignasi; Resch, Susanne; Alfaro-Serrano, Beatriz; Afantitis, Antreas; Melagraki, Georgia; Tse, Edmund C. M.; Trump, Josh; Kohl, Yvonne; Linkov, Igor (Peer reviewed; Journal article, 2023)As the governance of engineered nanomaterials (ENMs) evolves, innovations in the prevention, mitigation, management, and transfer of risk shape discussion of how nanotechnology may mature and reach various marketplaces. ... -
The comet assay applied to HepG2 liver spheroids
Elje, Elisabeth; Hesler, Michelle; Rundén-Pran, Elise; Mann, Pascal; Mariussen, Espen; Wagner, Sylvia; Dusinska, Maria; Kohl, Yvonne (Journal article; Peer reviewed, 2019)In accordance with the 3 Rs to reduce in vivo testing, more advanced in vitro models, moving from 2D monolayer to 3D cultures, should be developed for prediction of human toxicity of industrial chemicals and environmental ...